Evidence map›Paper›PMID 42782038›Full record

ArticleJACC. Case reports2026

ATTR-CM in Patients With Clinically Significant Plasma Cell Dyscrasias: A Case Series Highlighting Diagnostic Challenges.

Bhavya Ancha, Emily Brown, Mark Ranek, Nicole Lollo, Carol Ann Huff, Syed Abbas Ali, Christian B Gocke, Phillip Imus, Claire Brookmeyer, Charles Steenbergen and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Bhavya AnchaDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Emily BrownDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Mark RanekDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA.
Nicole LolloDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
Carol Ann HuffDepartment of Oncology, Johns Hopkins University, Baltimore, Maryland, USA.
Syed Abbas AliDepartment of Oncology, Johns Hopkins University, Baltimore, Maryland, USA.
Christian B GockeDepartment of Oncology, Johns Hopkins University, Baltimore, Maryland, USA.
Phillip ImusDepartment of Oncology, Johns Hopkins University, Baltimore, Maryland, USA.
Claire BrookmeyerDepartment of Radiology, Johns Hopkins University, Baltimore, Maryland, USA.
Charles SteenbergenDepartment of Pathology, Johns Hopkins University, Baltimore, Maryland, USA.
Michael PolydefkisDepartment of Neurology, Johns Hopkins University, Baltimore, Maryland, USA.
Joban VaishnavDepartment of Cardiology, Johns Hopkins University, Baltimore, Maryland, USA. Electronic address: jvaishn1@jhmi.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSuspicion and diagnosis of transthyretin cardiac amyloidosis (ATTR-CM) in patients with clinically significant plasma cell disorders is challenging. Timely identification of both light chain (AL) and ATTR-CM is essential for optimizing patient outcomes. CASE SUMMARY: We report 6 patients with clinically significant plasma cell disorders diagnosed with concomitant ATTR (4 variant and 2 wild-type), in whom genetic testing and endomyocardial biopsy led to accurate diagnosis. DISCUSSION: This case series highlights the diagnostic pitfall of assuming patients with suspected cardiac amyloidosis and clinically significant plasma cell dyscrasias have AL-CM. Tissue confirmation is required to accurately subtype cardiac amyloidosis in patients with plasma cell dyscrasias. Genetic testing is a valuable adjunct to refine pretest probability of ATTR-CM, particularly when diagnosis is uncertain or biopsy is deferred.

Indexed as

awarenessdiastolic heart failurerestrictive

Identifiers

PMID42782038
PMCPMC13616544

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.