ArticleJACC. Advances2026
Mitral Regurgitation after TAVR: Sex Differences and Low-Flow Low-Gradient Aortic Stenosis.
Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModerate or severe mitral regurgitation (MR) is common in patients with severe aortic stenosis (AS) treated with transcatheter aortic valve replacement (TAVR).
objectivesThe objectives of the study was to help define the prevalence and prognosis of persistent MR post-TAVR, particularly in women and in low-flow low-gradient (LFLG) AS.
methodsIn this single-center, observational study, 344 consecutive TAVR patients with severe AS and moderate or greater MR pre-TAVR were identified. Patients were stratified by AS subtype (classic vs LFLG). Factors associated with MR improvement to mild or less were evaluated using multivariable logistic regression. Survival was analyzed with Cox proportional hazards models adjusted for clinical and echocardiographic covariates.
resultsThe mean age was 81.9 years, 48.5% were females, and 45.1% had LFLG AS. MR improved by ≥1 grade in 62.8% and to mild or less in 52.9% of patients, with similar rates in classic vs LFLG AS. On multivariable analysis, severe (vs moderate) baseline MR, hypertension, and female sex were independently associated with lower odds of MR improvement to mild or less. In LFLG AS, female sex and severe MR remained significant predictors of persistent MR, whereas a higher pre-TAVR aortic valve mean gradient was associated with improved MR. Residual severe MR was associated with increased mortality, driven by those with LFLG AS.
conclusionsMore than half of TAVR patients with moderate or severe MR experience MR improvement post-TAVR. Women and those with severe MR are less likely to have a significant improvement in MR. Patients with LFLG AS and persistent moderate or severe MR have worse survival post-TAVR.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.