ArticleJournal of cardiovascular echography
Echocardiographic Strain-derived Predictors of Coronary Disease Burden Assessed by SYNTAX Score in Non-ST-elevation Acute Coronary Syndrome.
Article in Journal of cardiovascular echography. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Objective: The objective of this study was to evaluate whether global longitudinal strain (GLS), early systolic lengthening (ESL), and postsystolic shortening (PSS), individually and combined, predict anatomical disease severity and significant coronary artery stenosis in non-ST-elevation acute coronary syndrome (NSTE-ACS) with preserved left ventricular ejection fraction (LVEF). Materials and Methods: We prospectively enrolled 112 NSTE-ACS patients with preserved LVEF and no regional wall motion abnormalities. GLS, ESL, and PSS were measured using two-dimensional speckle-tracking echocardiography. Significant coronary artery disease (CAD) was defined as ≥90% stenosis in at least one major epicardial artery, and anatomical burden was quantified using the SYNTAX score. Linear and logistic regression, receiver-operating characteristic (ROC) analysis, DeLong comparison, and internal validation were performed. Results: GLS and PSS were significant predictors of SYNTAX score in univariate linear regression. In the multivariable model, only GLS remained independently associated with SYNTAX ( Conclusions: GLS is the strongest strain-derived predictor of both significant stenosis and anatomical CAD burden in NSTE-ACS with preserved LVEF. Strain-based analysis may aid early, noninvasive risk stratification in this population.
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