Evidence map›Paper›PMID 42781533›Full record

ArticleToxicon: X2026

Structural and functional characterisation of isolated puff adder (

Mark C Wilkinson, David T K Waterhouse, Cassandra M Modahl, Anthony J Saviola, Frank-Leonel Tianyi, Robert A Harrison, Nicholas R Casewell

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicon: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mark C WilkinsonCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.
David T K WaterhouseDeptartment of Tropical Disease Biology, Liverpool School of Tropical Medicine, Liverpool, UK.
Cassandra M ModahlCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.
Anthony J SaviolaDepartment of Biochemistry and Molecular Genetics, University of Colorado Denver, 12801 East 17th Avenue, Aurora, CO, 80045, USA.
Frank-Leonel TianyiCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.
Robert A HarrisonCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.
Nicholas R CasewellCentre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Serine proteases (SVSPs) are known to play a major role in the haemotoxic actions of viper venom, but compared with those from other medically important vipers, the serine proteases of puff adder venoms have not been extensively characterised. To address this, we isolated, identified and characterised the bioactivity of the serine proteases within the venom of the Nigerian puff adder, which we had previously shown to be especially rich in this class of toxin. Two distinct groups were identified, each with different protein substrate specificities. Both had similar molecular weights of 52-62 kDa, with 4-6 N-glycans, but one group consisted of trypsin-like acidic SVSPs and the other of non-trypsin-like basic SVSPs with a specificity for aliphatic amino acids at the P

Indexed as

Bitis arietansGelatinaseKallikrein-likeSerine proteaseSnake venom

Identifiers

PMID42781533
PMCPMC13599656

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.