SynthesisAlzheimer's & dementia : the journal of the Alzheimer's Association2026
A cell-type-resolved meta-analysis reveals glial DNA methylation changes associated with aging and Alzheimer's disease.
Synthesis in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Update of
Authors and funding
3 authors.
Funding
Abstract
introductionEpigenome-wide association studies implicate DNA methylation in Alzheimer's disease (AD) pathology. Although recent studies identified epigenetic signatures within non-neuronal cell types in disease risk, the role of the methylome in glial cell types (i.e., astrocytes, oligodendrocytes) in biological aging and AD pathogenesis is unclear.
methodsIn this study, we examined archived DNA methylation data across 13 cohorts and performed cell type deconvolution in silico to identify novel epigenetic signatures associated with aging and AD in glial cells.
resultsWe observed pronounced age-associated methylation signatures in astrocytes within the prefrontal cortex (PFC) and AD-associated methylation signatures in oligodendrocytes of the entorhinal cortex. Astrocytes and neurons within the PFC emerge as key players in Braak stage-associated methylation signatures. In oligodendrocytes, we observed amplification of age-related effects of DNA methylation signatures with AD. DISCUSSION: Our study expands on previous findings and reveals glial-specific methylation patterns associated with epigenetic aging and AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.