Evidence map›Paper›PMID 42781456›Full record

ArticleEuropean heart journal open2026

Right ventricular dysfunction in cardiogenic shock on temporary mechanical circulatory support.

Jan Estoppey, Iulia Maia Muresan, Matthias Bossard, Gregor Leibundgut, Gregor Fahrni, Stefan Blöchlinger, Roger Ludwig, Anna S Messmer, Valentin Köchli, Thomas Seiler and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04117230 (Clinical Outcomes in Patients in Need of a Non-permanent Extracorporeal Cardiocirculatory Support System), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04117230 recruitingnot on this map

Clinical Outcomes in Patients in Need of a Non-permanent Extracorporeal Cardiocirculatory Support System (Peripheral Extracorporeal Membrane Oxygenation (ECMO) or Axial Flow Pump IMPELLA)

Typeobservational_patient_registrySponsorInsel Gruppe AG, University Hospital BernRan2019 to 2034Enrolled1,500ConditionsCardiogenic Shock
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jan EstoppeyDepartment of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.ORCID https://orcid.org/0009-0001-7657-1788
Iulia Maia MuresanDepartment of Clinical Research, University of Bern, Freiburgstrasse 3, 3010 Bern, Switzerland.ORCID https://orcid.org/0009-0007-6537-3915
Matthias BossardCardiology Division, Heart Center Lucerne, Luzerner Kantonsspital, Kantonsspital 37, 6004 Lucerne, Switzerland.ORCID https://orcid.org/0000-0002-1587-2819
Gregor LeibundgutDepartment of Cardiology, University Hospital Basel, Petersgraben 4, 4031 Basel, Switzerland.ORCID https://orcid.org/0000-0002-0122-5397
Gregor FahrniDepartment of Cardiology, Stadtspital Zürich, Birmensdorferstrasse 497, 8063 Zürich, Switzerland.ORCID https://orcid.org/0009-0003-4527-5542
Stefan BlöchlingerDepartment of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.ORCID https://orcid.org/0009-0008-6290-3148
Roger LudwigDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.ORCID https://orcid.org/0009-0007-9876-3258
Anna S MessmerDepartment of Intensive Care Medicine, Inselspital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0002-3206-9112
Valentin KöchliDepartment of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.
Thomas SeilerDepartment of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0001-8325-2075
Armin SpahrCardiology Division, Heart Center Lucerne, Luzerner Kantonsspital, Kantonsspital 37, 6004 Lucerne, Switzerland.ORCID https://orcid.org/0009-0002-3771-7972
Alain M BernheimDepartment of Cardiology, Stadtspital Zürich, Birmensdorferstrasse 497, 8063 Zürich, Switzerland.ORCID https://orcid.org/0000-0001-5513-3503
Anna SchmidtDepartment of Cardiology, Kantonsspital Winterthur, Brauerstrasse 15, 8400 Winterthur, Switzerland.
Florim CuculiCardiology Division, Heart Center Lucerne, Luzerner Kantonsspital, Kantonsspital 37, 6004 Lucerne, Switzerland.ORCID https://orcid.org/0009-0000-3331-8128
Lukas HunzikerDepartment of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0003-0081-8518
Monika FürholzDepartment of Cardiology, Inselpital, Bern University Hospital, Freiburgstrasse 10, 3010 Bern, Switzerland.ORCID https://orcid.org/0000-0003-2366-6537

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims: Right ventricular dysfunction (RVD) is common in cardiogenic shock (CS) due to left ventricular failure and is associated with increased mortality, but its impact in patients requiring temporary mechanical circulatory support (tMCS) remains unclear. We explored RVD and its association with clinical outcomes in CS patients under tMCS. Methods and results: Individuals with CS from the SWISS Circulatory Support Registry (NCT04117230) were included. RVD was defined by ≥1 of the following parameters: tricuspid annular plane systolic excursion (TAPSE) < 14 mm, TAPSE/systolic pulmonary artery pressure (sPAP) < 0.34, right atrial pressure (RAP) > 15 mmHg, RAP/pulmonary capillary wedge pressure >0.63 or pulmonary artery pulsatility index (PAPi) < 1.85. The primary endpoint was 6-month mortality; secondary endpoints were hemodynamic stabilization markers. 745 patients were included: 580 supported with left-side-Impella-devices Conclusion: RVD was linked to increased mortality and worse haemodynamic stabilization in patients supported with Impella, whereas this association was not demonstrated in those under VA-ECMO. RV function is a key prognostic marker in CS patients under tMCS and should be assessed to guide device selection, management, and weaning.

Indexed as

Cardiogenic shockPercutaneous microaxial flow pumpRight ventricular dysfunctionTemporary mechanical circulatory supportVenoarterial extracorporeal membrane oxygenation

Identifiers

PMID42781456
PMCPMC13599024

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.