ArticleJournal of medical biochemistry2026
The influence of serum sterol sulfotransferase, ANGPTL8, and SDC1 on liver function in patients with intrahepatic cholestasis during pregnancy.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: To explore the relationships between serum Sterol Sulfotransferase, Recombinant Angiopoietin Like Protein 8 (ANGPTL8), and Recombinant Syndecan (SDC1) and liver function in patients with intrahepatic cholestasis of pregnancy (ICP), as well as their influence on perinatal outcomes. Methods: The control group comprised 200 healthy pregnant women who underwent physical examinations during the same period, while the study group comprised 210 ICP patients admitted to our hospital between June 2023 and December 2024. The study group's and the control group's serum Sterol Sulfotransferase, ANGPTL8, SDC1, and liver function markers were compared. Pearson correlation analysis was used to assess the relationships between serum levels of Sterol Sulfotransferase, ANGPTL8, and SDC1 and various liver function indicators. The patients in the study group were divided into a poor-outcome group (86 patients) and a good-outcome group (124 patients) based on perinatal outcomes. Serum Sterol Sulfotransferase, ANGPTL8, and SDC1 levels were examined between the groups with negative and positive outcomes. Factors predicting unfavourable perinatal outcomes in patients with ICPs were examined using univariate and multivariate logistic regression analyses. Results: Despite lower serum Sterol Sulfotransferase levels, the study group had higher levels of ANGPTL8 and SDC1 than the control group. P < 0 .0 5 indicated that the differences were statistically significant. The study group's levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were significantly higher than those of the control group (P<0.05). The Pearson correlation analysis showed that while the levels of ANGPTL8 and SDC1 were positively associated with AST, ALT, and ALP (P< 0.05), the level of serum Sterol Sulfotransferase was negatively associated with these levels. Compared to the group that experienced a positive outcome, the unfavourable outcome group's serum Sterol Sulfotransferase level was lower, whereas SDC1 and ANGPTL8 levels were greater than those in the group with favourable results. Decreased serum Sterol Sulfotransferase levels (S23 mmol/L), increased ANGPTL8 levels (650 pg/mL), and poor perinatal outcomes were associated with elevated SDC1 levels (53 ng/mL) in patients with ICP (P<0.05). Conclusions: Serum Sterol Sulfotransferase, ANGPTL8 and SDC1 are closely related to liver function and perinatal outcomes in patients with ICP. As the level of serum Sterol Sulfotransferase decreases and the levels of ANGPTL8 and SDC1 increase, it can lead to aggravated liver function impairment in patients with ICP, and it leads to adverse perinatal outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.