ArticleJournal of medical biochemistry2026
Correlation analysis of cytokine levels and peripheral blood T lymphocyte subsets in systemic vascular inflammatory disease.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To measure the levels of T-cell subsets andcytokines in the peripheral blood of patients with systemicvascular inflammatory disease and to analyse the influenceof different clinical characteristics of systemic vascularinflammatory disease patients on the levels of T-cell subsetsand cytokines in the peripheral blood. Methods: The case group included 80 patients with systemicvascular inflammatory disease who were diagnosed and trea -ted at our hospital between January 2021 and December2024. The control group consisted of 40 healthy volunteersrecruited from our hospital's health assessment centre. Theproportions of helper T-cell (Th)1, Th17, and regulatory Tcell (Treg) subsets in peripheral blood were analysed usingflow cytometry. Serum levels of cytokine, including interleukin-2 (IL-2), interferon-g (IFN-<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">γ</span>), tumour necrosis factor-a(TNF-<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span>), IL-4, IL-10, IL-17, and IL-6, were measured usingenzyme-linked immunosorbent assay (ELISA). Results: Compared with the control group, the expressionlevels of total T lymphoid subsets and CD8+ T and Th1 cellsin patients with systemic vascular inflammatory disease weresignificantly higher, and there was no statistically significantdifference in Th, Th17, or Treg cell expression between thegroups (P>0.05). However, there were statistically significantdifferences between the two groups [68.75 (54.23, 80.32)]and [72.10 (62.23, 86.45)], [23.44 (12.89, 33.76)] and[31.46 (20.13, 45.26)], [10.67 (8.23, 12.35)] and [10.26,17.96 [25.39)], Z=-3.13, -4.54, -3.97 (all P values<0.05).Compared with those in the control group, patients with systemic vascular inflammatory disease had significantly higherserum levels of IL-17, IL-6, TNF-<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span>, IL-4, and IFN-<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">γ</span>, whereastheir IL-10 levels were significantly lower. The differenceswere statistically significant (Z=-4.32, -5.01, -8.18, -8.70,-3.48, and -8.30). The P values were all <0.05. Comparedwith that in patients without related manifestations, IL-6expression was noticeably higher in systemic vascular inflammatory disease patients with arthritic symptoms and thosewith active systemic vascular inflammatory disease, and thedifference was statistically significant {pg/mL: [3.23 (2.98,5.35)] compared with [10.51 (6.72, 23.21)], [6.32 (4.79,8.93)] compared with [9.68 (6.97, 18.73)], Z=5.47, 8.76,P values <0.05}. Compared with those in patients withoutrelevant clinical manifestations, TNF-<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">α</span> levels were significantly higher in patients with arthritis, ocular, or digestive tractmanifestations, and in patients with active systemic vascularinflammatory disease, whereas IFN-<span style="color: rgb(32, 33, 34); font-family: sans-serif; font-size: 16px; background-color: rgb(248, 249, 250);">γ</span> levels were substantiallyhigher in systemic vascular inflammatory disease patientswith digestive system lesions. The differences were statistically significant {pg/mL: [7.74 (6.89, 10.19)] compared with[39.84 (30.37, 50.61)], [6.12 (5.36, 9.89)] compared with[31.35 (15.71, 30.46)], [6.49 (4.78, 10.21)] comparedwith [19.89 (14.36, 36.21)]. [5.89 (4.61, 8.96)] than[27.91 (15.32, 37.81)], [6.89 (5.43, 14.86)] than [26.79(15.41, 31.56)], Z= 7.70, 6.84, 6.94, 9.47, 5.70, P values<0.05}. However, there was no statistically significant difference in the expression levels of IL-4 and IL-17 between systemic vascular inflammatory disease patients with and without relevant clinical manifestations (P>0.05). Conclusions: Patients with systemic vascular inflammatorydisease exhibit an imbalance of T lymphocyte subsets andcytokines, and disease activity and clinical classificationmay also involve such imbalances.
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