ReviewFrontiers in nutrition2026
Lipid metabolism dysregulation in late-life depression: peripheral metabolic disturbance, central lipid alterations, and dietary modulation.
Review in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Late-life depression involves neurodegeneration, inflammation, metabolic disruption, and psychosocial stress. Lipid metabolism has drawn increasing attention in this field. This review examines three interconnected aspects: peripheral metabolic disturbance, potential central lipid alterations, and dietary lipid regulation. Peripherally, adverse lipid profiles and lipidomic shifts correlate with depressive symptoms, cognitive decline, and cardiometabolic load. Mechanisms include inflammation, membrane remodeling, mitochondrial dysfunction, and oxidative stress. Centrally, the disorder may involve aberrant membrane phospholipid metabolism, brain region-specific lipid alterations, and apolipoprotein E-mediated transport disruption, affecting myelin integrity, synaptic plasticity, neuroinflammation, and cerebrovascular function. Evidence regarding dietary lipids remains mixed: omega-3 supplementation has not shown a consistent preventive benefit, whereas high-fat, fried, and Western dietary patterns have been associated with depressive outcomes in observational studies. However, much of the current evidence is extrapolated from MDD or general populations, limiting its direct applicability to late-life depression. Future work should combine longitudinal designs, multi-omics, neuroimaging, and intervention studies to establish causality and identify biomarkers and tailored strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.