Evidence map›Paper›PMID 42781375›Full record

ArticleRespiratory research & clinical practice2026

Prognostic impact of pre- and post-bronchodilator airflow obstruction and post-bronchodilator reference values in a population-based study. On behalf of the PLATINO group.

Rogelio Pérez-Padilla, Maria Montes de Oca, Ireri Thirion-Romero, Maria Victorina Lopez, Jose R Jardim, Adriana Muino, Gonzalo Valdivia, Ana Maria B Menezes

Abstract readMulticenter Study
In one paragraph

Article in Respiratory research & clinical practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rogelio Pérez-Padilla. Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.ORCID 0000-0002-1132-5308
Maria Montes de Oca. División de Neumología, Hospital Universitario de Caracas, Universidad Central de Venezuela y Centro Médico de Caracas, Caracas, Venezuela.ORCID 0000-0002-5274-7574
Ireri Thirion-Romero. Instituto Nacional de Enfermedades Respiratorias, Ciudad de México, México.ORCID 0000-0002-9038-2588
Maria Victorina Lopez. Universidad de la República, Hospital Maciel, Montevideo, Uruguay.ORCID 0000-0002-8360-1551
Jose R Jardim. Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo (SP) Brasil.ORCID 0000-0002-7178-8187
Adriana Muino. Universidad de la República, Hospital Maciel, Montevideo, Uruguay.ORCID 0000-0002-7139-1286
Gonzalo Valdivia. Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID 0000-0001-5368-6745
Ana Maria B Menezes. Programa de Pós-Graduação em Epidemiologia, Universidade Federal de Pelotas, Pelotas (RS) Brasil.ORCID 0000-0002-2996-9427

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Post-bronchodilator (BD) spirometry testing is required for a diagnosis of airflow obstruction (AO) and COPD. We compared the impact of pre- and post-BD AO, as well as that of pre-BD and post-BD reference values, on survival, exacerbations, and FEV Methods: We analyzed data derived from the Proyecto Latinoamericano de Investigación en Obstrucción Pulmonar (PLATINO, Latin American Project for the Investigation of Obstructive Lung Disease) study, involving individuals residing in three Latin American cities and evaluated 5-9 years after baseline examination. Categories were formed by pre-and post-BD FEV Results: At baseline, 2,942 participants completed pre- and post-BD spirometry; 2,262 were normal (controls); 139 had pre-BD AO (FEV Conclusions: Individuals with post-BD AO identified only with post-BD reference values had an increased risk of death. Those with pre-BD AO had higher mortality and an increased risk of developing COPD, therefore requiring close follow-up monitoring and being classified as pre-COPD patients.

Indexed as

Bronchodilator AgentsPopulation SurveillancePulmonary Disease, Chronic ObstructiveSpirometryAgedFemaleForced Expiratory VolumeHumansMaleMiddle AgedPrognosisReference ValuesBronchodilator AgentsAirflow obstruction, chronicMortalityPulmonary disease, chronic obstructiveReference valuesSpirometry

Identifiers

PMID42781375
PMCPMC13598867

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.