ArticleDEN open2027
Submucosal Invasion and Ulceration in Early Gastric Cancer Affect Mucosal Impedance.
Article in DEN open, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To investigate early changes in gastric cancers that are difficult to evaluate using endoscopic imaging through the assessment of mucosal impedance (MI) in endoscopic submucosal dissection (ESD) specimens. Methods: In this single-center prospective cohort study, we included patients who underwent ESD for early gastric cancer (EGC). MI was measured at both the main tumor site and the surrounding non-neoplastic mucosa in resected specimens. Histopathological evaluation and immunohistochemical staining for claudin-3, -4, and -18 were performed. Furthermore, multivariate analysis was used to investigate factors influencing MI-L. Results: The MI measured under high-frequency current (MI-H) of the non-neoplastic mucosa was significantly higher than that of the tumor ( Conclusions: In resected specimens, MI-L was independently associated with claudin-18 expression and correlated with submucosal invasion, ulcer status, and macroscopic type. MI has the potential to detect non-surface changes involving tight junction proteins in EGC that cannot be observed via endoscopy.
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