Evidence map›Paper›PMID 42781259›Full record

ArticleBioactive materials2027

A bladder microenvironment-adaptive ceria nanozyme hydrogel enables urea-responsive intravesical chemo-immunotherapy.

Yulin Yuan, Linkang Yu, Huayi Feng, Chuanjie Li, Xiaogang Chen, Longbao Feng, Teijun Pan, Lei Gao, Yu Zhou, Ling Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yulin YuanMedical College, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China.
Linkang YuMedical College, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China.
Huayi FengDepartment of Urology, General Hospital of Central Theater Command of the People's Liberation Army, Wuhan, Hubei, 430000, China.
Chuanjie LiMedical College, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China.
Xiaogang ChenDepartment of Urology, Huangshi Central Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei, 435000, China.
Longbao FengKey Laboratory of Biomaterials of Guangdong Higher Education Institutes, Guangdong Provincial Engineering and Technological Research Centre for Drug Carrie Development, Department of Biomedical Engineering, Jinan University, Guangzhou, 510632, China.
Teijun PanMedical College, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China.
Lei GaoMedical College, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China.
Yu ZhouMedical College, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, China.
Ling ZhangHealthy Hubei Development and Social Progress Research Center of the Key Research Base of Humanities and Social Sciences in Hubei Province, School of Public Health, Wuhan University of Science and Technology, Wuhan, 430065, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer intravesical therapy remains limited by rapid urinary washout, insufficient penetration across the bladder mucosal barrier, and an immunosuppressive tumor microenvironment. Here, we developed a bladder microenvironment-adaptive chemo-immunotherapy system, Gel/UCeNZ/Gem/CpG, to improve local bladder cancer treatment. In this system, urease-modified CeO

Indexed as

Bladder cancerCeria nanozymeImmunogenic cell deathIntravesical chemo-immunotherapyUrea-responsive delivery

Identifiers

PMID42781259
PMCPMC13598521

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.