ArticleJournal of medical biochemistry2026
The role of serum BAFF, CFB, MCP-1 and anti-PLA2R antibodies in the efficacy evaluation of patients with membranous nephropathy.
Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Monocyte chemoattractant protein-1 (MCP-1), serum B-cell activating factor (BAFF), complement B factor (CFB), and anti-M-type phospholipase A2 receptor (PLA2R) antibodies are investigated in relation to membranous nephropathy (MN), and their roles in evaluating treatment efficacy are assessed. Methods: 108 patients who were hospitalised to our hospital between January 2023 and June 2024 were chosen to serve as research participants. Patients were divided into remission and nonremission groups based on clinical efficacy. The levels of serum BAFF, CFB, MCP-1, and anti-PLA2R antibodies in patients with positive and negative anti-PLA2R and at different pathological stages were compared, and the clinical data of the remission and nonremission groups were compared. The association between serum levels of BAFF CFB, and MCP-1 and anti-PLA2R antibody levels in patients who tested positive for anti-PLA2R antibody. The predictive efficacy of serum anti-PLA2R antibodies, BAFF, CFB, and MCP-1 for nonremission after therapy in MN patients was evaluated using receiver operating characteristic (ROC) curves. Results: There were 78 patients who were positive for anti-PLA2R antibodies and 30 patients who were negative for anti-PLA2R antibodies. The levels of serum BAFF CFB, MCP-1 and anti-PLA2R antibodies in patients positive for anti-PLA2R antibodies were significantly greater than those in patients negative for anti-PLA2R antibodies (P< 0,05). The comparison of serum BAFF CFB, and MCP-1 levels in MN patients at different stages was as follows: stage I < stage II < stage III < stage IV Serum BAFF, CFB, and MCP-1 in patients positive for anti-PLA2R antibodies were positively correlated with the level of anti-PLA2R antibodies (r= 0.792, 0.823, 0.832, P< 0.001). Spearman correlation analysis revealed that serum BAFF, CFB, and MCP-1 levels in MN patients were positively correlated with pathological stage (rs= 0.758, 0.752, and 0.717, respectively; P< 0.001). The pathological stage and levels of anti-PLA2R antibody, BAFF, CFB, and MCP-1 were significantly higher in the nonremission group than in the remission group (P< 0.05). After treatment, elevated serum levels of MCP-1, CFB, and BAFF were risk factors for nonremission in MN patients (P< 0.05). The ROC curve analysis revealed that the area under the curve for the combined prediction of nonremission in MN patients after treatment with serum BAFF, CFB and MCP-1 was 0.948, which was greater than the area under the curve for the individual prediction of anti-PLA2R antibody and BAFF, CFB and MCP-1 (Z = 4.116 , 3.059, 4.122, 4.116, P<0.05). Conclusions: Serum levels of BAFF, CFB, and MCP-1 in MN patients are associated with anti-PLA2R antibody levels, MN stage, and therapeutic effect. Moreover, the combined detection of serum BAFF, CFB, and MCP-1 has high predictive value for nonremission after treatment in MN patients.
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