Effect Of treatment on serum C3, C4, IL-10, IL1-β, IL-6, TNF-α in patients with systemic lupus erythematosus.

Nadira Reyimu, Yueyue Jing

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Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

2 authors.

Nadira ReyimuThe Second Affiliated Hospital of Xinjiang Medical University, Department of of Cardiovascular, Urumqi, Xinjiang, China.

Yueyue JingYan'an People's Hospital, Department of Cardiovascular Medicine, Yan'an, Shaanxi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This study aimed to evaluate the effects of structured lifestyle optimisation, including nutritional intake and exercise training, on serum levels of Complement C3, C4, IL-10, IL1-β, IL-6, and TNF-α in patients with systemic lupus erythematosus (SLE) and Libman-Sacks endocarditis (LSE). Methods: A total of 122 SLE patients with LSE, treated at our hospital from May 2022 to May 2024, were randomised into a control group (CG, n = 61) receiving conventional medical interventions and an intervention group (IG, n = 61) receiving additional personalised exercise and nutritional interventions for 24 weeks. Serum levels of Complement C3, C4, IL-10, IL1-β, IL-6, and TNF-α were measured at baseline, 3 months, and 6 months. Secondary endpoints included nutritional status (as measured by albumin and haemoglobin levels) and patient compliance. Results: Of 113 patients completing the study, the intervention group (IG) showed significant improvement in serum Complement C3 (0.84 ± 0.18 g/L vs. 0.75± 0.16 g/L in the control group [CG], P= 0.006) and albumin levels (37.12± 5.37 g/L vs. 35.00 ± 4.89 g/L, P= 0.03) at 6 months. Complement C4 levels increased in the IG (0.20 ± 0.09 g/L vs. 0.17± 0.12 g/L, P= 0.136, not significant). IL-1β (3 .9 ± 3 .7 7 pg/mL vs. 4.6± 4.1 pg/mL, P= 0.468) and TNF-α (12.6± 4.1 pg/mL vs. 14.1 ±5.2 pg/mL, P= 0.092) showed non-significant reductions in the IG compared to the CG. No significant changes were observed in IL-10 or IL-6 levels. Compliance was significantly higher in the IG (92.86% vs. 78.95% , P= 0.038). Conclusions: Structured lifestyle optimisation significantlyimproved serum Complement C3 and albumin levels andshowed non-significant trends toward reductions in IL-1β and TNF-α in SLE patients with LSE, suggesting a potentialadjunctive role in managing immune and nutritional status.

Indexed as

complement C4exercise trainingIL-10IL1-βIL-6Libman-Sacks endocarditislifestyle optimisationnutritional interventionsserum complement C3systemic lupus erythematosusTNF-α

Identifiers

PMID42781170

DOI10.5937/jomb0-62357

PMCPMC13600646

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.