Evidence map›Paper›PMID 42781113›Full record

ArticleNature reviews. Materials2026

Replace the vitreous permanently.

André Schulz, Katelyn E Swindle-Reilly, Gopal Lingam, Maximilian Hammer, Zengping Liu

Abstract read
In one paragraph

Article in Nature reviews. Materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

André SchulzDepartment of Ophthalmology, Rostock University Medical Center, Rostock, Germany.ORCID 0000-0003-2445-9118
Katelyn E Swindle-ReillyDepartment of Biomedical Engineering, The Ohio State University, Columbus, OH, USA.
Gopal LingamDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Maximilian HammerThe David J Apple Laboratory for Vision Research, Department of Ophthalmology, University Clinic Heidelberg, Heidelberg, Germany.
Zengping LiuDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-2578-293X

Funding

The impact of age-related vitreous degeneration and vitreous replacement on scleral biomechanics: a novel mechanism and treatment target for glaucomaR21EY035035 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIANCO, GIANFRANCO · 2023 to 2024
$429k
NEI NIH HHS R21 EY035035
6 · The paper itself

Abstract

Vitreous substitutes remain a fundamental unmet need in regenerative medicine: current tamponade agents, gases and silicone oil, address immediate surgical challenges but neglect the long-term functional role of the tissue they replace. A paradigm shift towards durable, biomimetic hydrogel substitutes is not a distant ambition, but a clinical necessity.

Identifiers

PMID42781113
PMCPMC13598403

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.