ArticleLaryngoscope investigative otolaryngology2026
Modeling the Relationship of Age With Hypocalcemia Following Total Thyroidectomy: A NSQIP Analysis.
Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
Objective: To characterize the relationship between age and hypocalcemia risk following total thyroidectomy and identify critical age-related transition points across the lifespan. Methods: The American College of Surgeons National Surgical Quality Improvement Program Thyroidectomy Targeted database was queried for 21,109 adult patients (18+) from 2016 to 2023 who underwent total thyroidectomy. Multivariate regressions utilizing age, sex, race/ethnicity, BMI, surgical specialty, ASA classification, and surgical indication were used to assess odds of hypocalcemia within 30 days of surgery. Additionally, age-stratified analyses, generalized additive modeling (GAM), and segmented regression were used to assess odds of hypocalcemia. Results: Age was independently associated with 2% decreased odds of hypocalcemia per year older (OR, 0.98; 95% CI, 0.98-0.99; Conclusion: Hypocalcemia risk following total thyroidectomy follows a nonlinear age-dependent pattern with identifiable transitions, challenging simple continuous or categorical age modeling. Risk stabilizes after the mid-sixties, though very elderly patients should not be assumed to have lower risk due to advanced age alone. These findings support development of age-tailored risk stratification tools for more personalized perioperative calcium management. Level of Evidence: 4.
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