Development of soy protein isolate-based orally disintegrating films: The dual role of β-Cyclodextrin in enhancing disintegration performance and ergothioneine stability.

Yaxin Zhou, Xiaoyu Du, Chanting Lv, Yachao Tian, Shutao Guo, Zengwang Guo, Zhongjiang Wang

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Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Yaxin ZhouState Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin, 300071, China.

Xiaoyu DuCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.

Chanting LvCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.

Yachao TianCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.

Shutao GuoState Key Laboratory of Medicinal Chemical Biology, Institute of Polymer Chemistry, Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin, 300071, China.

Zengwang GuoCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.

Zhongjiang WangCollege of Food Science, Northeast Agricultural University, Harbin, Heilongjiang, 150030, China.

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6 · The paper itself

Abstract

Plant protein-based orally disintegrating films (ODFs) are promising but limited by slow disintegration and poor stability of incorporated actives. This study developed ergothioneine (EGT)-loaded soy protein isolate (SPI) ODFs and investigated the bifunctional regulatory effects of β-CD. β-CD exerts a dual role as both a structural modulator and a stability-enhancing additive. At 10% (w/w) dosage, β-CD remodeled the SPI network into a more hydrophilic structure, shortening in vitro disintegration time to 15.46 s and enhancing tensile strength to 12.15 MPa. Furthermore, β-CD incorporation was associated with improved retention of total antioxidant activity in EGT-loaded films during accelerated storage, likely attributable to reduced oxidative exposure via intermolecular interactions within the film matrix. Excessive β-CD (15%,

Indexed as

Antioxidant activity retentionErgothioneineOrally disintegrating filmsSoy protein isolateβ-Cyclodextrin

Identifiers

PMID42781022

DOI10.1016/j.fochx.2026.104451

PMCPMC13599665

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