Evidence map›Paper›PMID 42781015›Full record

ArticleMaterials today. Bio2026

Neuroimaging of indoleamine 2,3-dioxygenase 1 (Ido1) in Alzheimer's disease: Development of a novel

Hua Cheng, Nilay S Narayan, Yongle Wang, Yanli Wang, Yafei Huang, Hongzhi Yang, Ramya Tokala, Jinwu Yan, Joseph William Downey, Anne Siewko and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Hua ChengAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Nilay S NarayanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Yongle WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Yanli WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Yafei HuangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Hongzhi YangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Ramya TokalaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Jinwu YanAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Joseph William DowneyAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Anne SiewkoAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Breanna Lizeth VarelaAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Madelyn Rose HalliseyAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Tiffany A GeronimoAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Mary Margaret BanickAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Rudolph E TanziGenetics and Aging Research Unit, Department of Neurology, McCance Center for Brain Health, Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, United States.
Can ZhangGenetics and Aging Research Unit, Department of Neurology, McCance Center for Brain Health, Massachusetts General Institute for Neurodegenerative Disease, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, United States.
Yulong XuAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.
Changning WangAthinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, United States.

Funding

BET-BD1 Selective Neuroimaging probes for Alzheimer's disease researchRF1AG081195 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI WANG, CHANGNING, ZHANG, CAN MARTIN · 2023 to 2023
$2.4M
New epigenetic inhibitors for Alzheimer's disease treatmentR01AG086433 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Changning Wang, Can Martin Zhang · 2024 to 2026
$2.4M
BET-BD1 Selective Neuroimaging probes for Alzheimer's disease researchR01AG081195 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Changning Wang, Can Martin Zhang · 2026 to 2026
$805k
LC/MS Replacement for Institute for Innovation in Imaging Core Facility.S10OD034259 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, JOHN W · 2024 to 2024
$311k
NIA NIH HHS R01 AG081195NIA NIH HHS R01 AG086433NIA NIH HHS RF1 AG081195NIH HHS S10 OD034259
6 · The paper itself

Abstract

IDO1-mediated dysregulation of the kynurenine pathway is a pivotal driver of neuroinflammation in Alzheimer's disease (AD). Despite its clinical significance, PET probes specifically targeting IDO1 in the AD brain remain scarce. In this study, we first established a strong correlation between IDO1 expression and AD progression through bioinformatic analysis. Subsequently, a novel PET tracer, [

Indexed as

Alzheimer's diseaseIDO1Molecule imagingNeurodegenerationNeuroimaging

Identifiers

PMID42781015
PMCPMC13598165

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.