Evidence map›Paper›PMID 42780986›Full record

ArticleiScience2026

Lymph node extracellular matrix skews the immune function of human fibroblastic reticular cells.

Daphne Panocha, Janna E G Roet, Michael de Kok, Tanja Konijn, Henk P Roest, Luc J W van der Laan, Charlotte M de Winde, Reina E Mebius

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Daphne PanochaAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Molecular Cell Biology & Immunology, De Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands.
Janna E G RoetAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Molecular Cell Biology & Immunology, De Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands.
Michael de KokAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Molecular Cell Biology & Immunology, De Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands.
Tanja KonijnAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Molecular Cell Biology & Immunology, De Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands.
Henk P RoestErasmus MC Transplant Institute, University Medical Center Rotterdam, Department of Surgery, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
Luc J W van der LaanErasmus MC Transplant Institute, University Medical Center Rotterdam, Department of Surgery, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
Charlotte M de WindeAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Molecular Cell Biology & Immunology, De Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands.
Reina E MebiusAmsterdam UMC Location Vrije Universiteit Amsterdam, Department of Molecular Cell Biology & Immunology, De Boelelaan 1117, 1081 HZ Amsterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymph node (LN) fibroblastic reticular cells (FRCs) are key immunomodulators that regulate adaptive immune responses and provide structural support via extracellular matrix (ECM) production. However, how ECM composition shapes FRC-immune cell interactions remains unclear. Here, we show that ECM composition, specifically collagen type I, laminin α4, or laminin α5, critically determines the immunological status of human FRCs. Bulk RNA sequencing shows that FRCs grown on collagen closely resemble those in native human LN ECM, whereas laminin α4 and α5 differentially skew FRC transcriptomes toward homeostatic/tolerogenic or pro-inflammatory profiles, respectively. These ECM-imprinted FRC states subsequently shape distinct CD4

Indexed as

adaptive immunityextracellular matrixfibroblastic reticular celllamininlymph nodeT cell

Identifiers

PMID42780986
PMCPMC13599584

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.