ArticleNeuro-oncology advances
Re-resection at first recurrence is associated with prolonged survival in young patients with high-grade glioma: A multi-center study.
Article in Neuro-oncology advances. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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22 authors.
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Abstract
Background: Surgical resection remains standard of care for high-grade glioma. It is unclear, however, whether re-resection at the time of first recurrence confers further survival benefit in young patients. Methods: This multi-center, retrospective cohort study included patients age 0-21 years with supratentorial high-grade glioma who underwent gross total or near total resection at time of initial diagnosis which subsequently recurred. Patients were grouped by therapeutic re-resection at first recurrence. Post-recurrence overall survival was assessed with Kaplan-Meier methods, multivariable Cox regression, and propensity score-matched analyses. Results: Forty-four patients with a median age of 12.5 years from 7 institutions were included. 61% ( Conclusions: Therapeutic re-resection at first recurrence was associated with improved post-recurrence survival, which remained significant after multivariable adjustment or propensity score matching. This study provides evidence for re-resection in recurrent high-grade glioma in young patients.
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