ArticleFrontiers in nutrition2026
A polyherbal and probiotic-based immunostimulatory formulation for managing gut dysbiosis in colorectal cancer.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The prevention of colorectal cancer (CRC) and its possible relapse remains a daunting challenge due to the unclear mechanisms governing gut dysbiosis and its interaction with the gut-immune axis. The present study aimed to investigate the preventive role of a polyherbal immunostimulatory formulation to restoring microbial diversity in gut and preventive management of colon cancer. Methods: We developed a novel polyherbal and probiotic-based immunostimulatory formulation with four variants (F3A, F3B, F3C, and F3D), incorporating botanical extracts and probiotics. Initially, plant-derived biological lead compounds were identified using LC/MS/MS. Next, the identified biological leads were subjected to Results: Formulation F3B showed maximal cytotoxicity in CT26 cell line however it considered for animal experiments. Thereafter, Discussion: Our findings demonstrate that the proposed formulations exhibit anti-proliferative, mild pro-apoptotic, immunomodulatory, and antimicrobial effect. Based on 16S rRNA sequencing results, F3B demonstrated better outcomes toward managing gut dysbiosis in female BALB/C mice. However, we can conclude that formula 3FB can be used as preventive approach to control gut dysbiosis and possible colon cancer relapse.
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