Evidence map›Paper›PMID 42780918›Full record

ArticleFrontiers in nutrition2026

The impact of low carbohydrate diet on the plasma proteomic profile of individuals with obesity.

Nora A Alfadda, Ghadeer S Aljuraiban, Salini Scaria Joy, Heba Elkhateb, Shahed Nawaz, Othman Mahmoud Othman, Osama Z Alzeer, Abdullah Abdulaziz Al Wabel, Assim A Alfadda, Hicham Benabdelkamel

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In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nora A AlfaddaDepartment of Community Health Sciences, Clinical Nutrition, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Ghadeer S AljuraibanDepartment of Community Health Sciences, Clinical Nutrition, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.
Salini Scaria JoyStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Heba ElkhatebProteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Shahed NawazProteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Othman Mahmoud OthmanProteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Osama Z AlzeerDepartment of Clinical Nutrition, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia.
Abdullah Abdulaziz Al WabelUniversity Diabetes Center, King Saud University, Riyadh, Saudi Arabia.
Assim A AlfaddaStrategic Center for Diabetes Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Hicham BenabdelkamelProteomics Resource Unit, Obesity Research Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Obesity is a major public health concern worldwide and contributes to multiple metabolic disorders. Low carbohydrate diets (LCDs) have been proposed as an effective strategy for weight management and metabolic improvement; however, the mechanisms underlying LCD-induced molecular changes in individuals with obesity remain incompletely understood. This study aimed to assess the impact of a three-month LCD on the proteomic profile of adults with obesity. Methods: Thirty adults (18-50 years) with obesity (BMI ≥ 30 kg/m Results: Overall, the LCD was associated with significant reductions in body weight, BMI, waist and hip circumferences, fat mass and percentage, GGT, triglycerides, and HbA1c (paired Conclusion: A three-month LCD significantly improved anthropometric and metabolic parameters in adults with obesity and was associated with marked changes in the plasma proteome. Distinct proteomic signatures between responders and non-responders highlight inter-individual variability in biological response, supporting the potential of plasma proteomics for biomarker discovery and precision nutrition in obesity management.

Indexed as

dietary interventionlow carbohydrate dietobesityomicsplasma proteomicsweight loss

Identifiers

PMID42780918
PMCPMC13599130

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.