Evidence map›Paper›PMID 42780907›Full record

ArticleFrontiers in medicine2026

Clinical characteristics of necrotizing enterocolitis occurring within the first week of life in low-birth-weight preterm infants: a multicenter retrospective study.

Jiexia Gao, Jie Fu, Fan He, Yanbin An, Jinglin Xu, Bowen Weng, Chongbing Yan, Yuanyang Zhang, Na Zhuo, Jiahuai Liu and 4 more

Abstract read
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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Jiexia Gao *Department of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Jie Fu *Department of Neonatology, Bozhou Children's Hospital, The People's Hospital of Bozhou, Bozhou, Anhui, China.
Fan He *Neonatal Intensive Care Unit, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China.
Yanbin An *Neonatology Division, Inner Mongolia Maternity and Child Health Care Hospital, Hohhot, Inner Mongolia, China.
Jinglin Xu *Department of Neonatology, Quanzhou Maternity and Children's Hospital, Quanzhou, Fujian, China.
Bowen WengDepartment of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Chongbing YanDepartment of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yuanyang ZhangDepartment of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Na ZhuoNeonatology Division, Inner Mongolia Maternity and Child Health Care Hospital, Hohhot, Inner Mongolia, China.
Jiahuai LiuDepartment of Neonatology, Quanzhou Maternity and Children's Hospital, Quanzhou, Fujian, China.
Cong YuNeonatal Intensive Care Unit, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China.
Dongmei ChenDepartment of Neonatology, Quanzhou Maternity and Children's Hospital, Quanzhou, Fujian, China.
ArigonggaowaNeonatology Division, Inner Mongolia Maternity and Child Health Care Hospital, Hohhot, Inner Mongolia, China.
Cheng CaiDepartment of Neonatology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aimed to compare the perinatal background, clinical characteristics, and outcomes of low-birth-weight preterm infants with Necrotizing enterocolitis (NEC) occurring within the first week of life and those with NEC occurring after the first week of life. Methods: This multicenter retrospective study included preterm infants with a birth weight <2,500 g who were diagnosed with NEC within 28 days of life across five neonatal intensive care units from January 2021 to June 2024. Infants were classified according to age at NEC onset into an early-onset NEC group (EO-NEC, ≤7 days) and a later-onset NEC group (LO-NEC, >7 days). Perinatal characteristics, disease severity, hematological parameters, imaging findings, treatment, and short-term outcomes were compared between groups. Results: Among 405 eligible infants, 151 (37.3%) developed EO-NEC. Compared with LO-NEC infants, EO-NEC infants had higher gestational age and birth weight but were more likely to be small for gestational age (SGA) and exposed to maternal hypertensive disorders. EO-NEC was also associated with a higher proportion of non-full enteral feeding before onset, Bell stage III disease, intestinal perforation, thrombocytopenia, and higher hemoglobin and hematocrit levels. However, surgical intervention and mortality did not differ significantly between groups. Conclusion: These findings suggest that NEC occurring within the first week of life has several characteristic clinical features and may help identify infants who require closer abdominal and hematological monitoring.

Indexed as

clinical characteristicsearly onsetlow birth weightnecrotizing enterocolitispreterm infants

Identifiers

PMID42780907
PMCPMC13597887

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