ArticleTalanta open2026
An amplification-free fluorescence turn-on sensing platform for in situ monitoring miRNA release from live cells.
Article in Talanta open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
MicroRNAs (miRNAs) are key regulators of numerous physiological and pathological processes and hold substantial promise for disease diagnosis and therapeutic evaluation. Although a variety of quantitative miRNA assays have been reported, none are suitable for real-time monitoring of miRNA release from live cells due to prolonged assay times, insufficient sensitivity, or interference from complex sample matrices. Herein, we report a novel amplification-free assay based on hybridization of a single-stranded DNA (ssDNA) probe to the target miRNA and fluorescence readout of the resulting DNA-RNA heteroduplex using the RNA-selective intercalating dye SYBR Green II. The proposed assay enables quantitative detection of target miRNAs with a detection limit of 9.1pM and a linear fluorescence response across a concentration range of 25 to 200pM (R
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