ArticleHealth science reports2026
Impact of Sickle Cell Hemoglobin Genotypes on Clinical Outcomes Among
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sickle cell anemia (SCA) may influence malaria susceptibility and clinical outcomes in endemic regions. However, the interaction between hemoglobin genotypes and malaria severity remain poorly defined in endemic African settings, particulary in Angola, where SCA and malaria impose a substantial public health burden. Herein, we investigate associations between hemoglobin genotypes and clinical outcomes among malaria patients. Methods: This was a prospective cohort study conducted with 252 malaria patients in Luanda, the capital city of Angola, a sub-Saharan African country. Association between hemoglobin genotypes and demographic, geographic, parasitological, and clinical variables were assessed in relation to malaria outcomes. Results: HbAA was predominant (75.0%), followed by HbAS (16.7%) and HbSS (8.3%). Mean age did not differ significantly across genotypes ( Conclusions: Our findings suggest that HbSS may be associated with increased malaria morbidity and mortality in Angola. Further studies incorporating molecular characterization of malaria parasites are needed to elucidate clinical trajectories and parasite-host interactions.
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