Evidence map›Paper›PMID 42780731›Full record

ArticleJournal of medical biochemistry2026

Correlation analysis of FABP3, MCP-4, and CXCL9 levels and myocardial damage in patients with severe pneumonia.

Longxia Du, Jianping Wang, Zongxian Wu, Xianxin Lai, Xuanchen Qian

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Article in Journal of medical biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Longxia DuThe Second Affiliated Hospital of Chengdu Medical College, Department of Pulmonary and Critical Care Medicine-Section 2, Chengdu City, China.
Jianping WangEzhou Central Hospital, Department of Critical Care Medicine, Ezhou City, China.
Zongxian WuHunan Provincial People's Hospital, Department of Intensive Care Unit, Changsha City, China.
Xianxin LaiHunan Provincial People's Hospital, Department of Intensive Care Unit, Changsha City, China.
Xuanchen QianThe Affiliated Hospital of Xuzhou Medical University, Neurosurgical Intensive Care Unit, Xuzhou City, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: To explore the correlations between the levelsof serum monocyte chemoattractant protein-4 (MCP-4),heart-type fatty acid binding protein (FABP3), andchemokine ligand 9 (CXCL9) and myocardial damage insevere mycoplasma pneumonia (SMPP) patients. Methods: A total of 158 patients with severe mycoplasmapneumonia complicated with myocardial damage wereincluded in the SMPP group. They were divided into amyocardial damage group (n=42) and a nonmyocardialdamage group (n = 116) according to whether myocardialdamage occurred. The control group consisted of an additional 102 healthy people who were examined throughoutthe same time period. The levels of serum MCP-4, FABP3and CXCL9 in the two groups were compared. The patients'general clinical data were recorded. Multivariate logisticregression was used to identify risk factors for myocardialinjury in patients with severe mycoplasma pneumonia. Results: The levels of serum MCP-4, FABP3 and CXCL9 inthe SMPP group were significantly greater (all P<0.05).Compared with those in the nonmyocardial damage group,serum MCP-4, FABP3, and CXCL9 levels were considerablyhigher (all P< 0.05) in the group with myocardial injury Age, sex, diabetes, smoking history, hypoxemia, jaundice,and chronic obstructive pulmonary disease (COPD) did notdiffer statistically significantly between the two groups (allP> 0.05). Compared with those in the nonmyocardial damage group, the proportions of patients with hypertension,coronary heart disease, and anaemia, as well as the levelsof serum MCP-4, FABP3, and CXC L9, in the myocardialdamage group were significantly higher (all P<0.05).Combined hypertension, coronary heart disease, anaemia,and high levels of serum MCP-4, FABP3, and CXCL9 arerisk factors for myocardial damage in patients with severemycoplasma infection. The levels of serum MCP-4, FABP3and CXCL9 in patients were positively correlated with theincidence of myocardial damage in patients with severemycoplasma infection (all P< 0.05). Conclusions: The levels of serum MCP-4, FABP3 and CXCL9are positively correlated with myocardial damage in patientswith severe mycoplasma pneumonia. Moreover, combinedhypertension, coronary heart disease, anaemia and high levels of serum MCP-4, FABP3 and CXCL9 are risk factors formyocardial damage in patients with severe mycoplasma infection. These three factors can serve as biological indicatorsof myocardial damage in patients with severe mycoplasmainfection in clinical practice and are highly important forassessing patients' conditions and formulating treatmentplans.

Indexed as

chemokine ligand 9correlation analysisheart-type fatty acid binding proteinmonocyte chemoattractant protein-4myocardial damagesevere mycoplasma pneumonia

Identifiers

PMID42780731
PMCPMC13598772

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