ArticleFrontiers in immunology2026
Adaptive resilience: agarikon mycelium modulates immune responses and provides oxidative stress buffering in human immune cells.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Agarikon ( Methods: To provide a stronger mechanistic basis for the observed preclinical and clinical effects supported by agarikon mycelium, this preclinical study investigated the transcriptomic effects of agarikon mycelium in human peripheral blood mononuclear cells (PBMCs) under both basal and LPS-stimulated conditions ( Results: Under basal conditions, agarikon mycelium selectively engaged the innate immune response through IL-1 and NF-κB axes, balanced by increases in anti-inflammatory mediators such as IL-1RA and decreases in toll-like receptor transcripts. Under LPS-stimulated conditions, this innate immune response was modified, with measured increases in immune effectors (including Conclusion: Overall, agarikon mycelium demonstrated a coordinated, context-dependent immune response profile, supporting its stress-buffering and immune-modulating potential and warranting continued clinical validation.
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