Evidence map›Paper›PMID 42780585›Full record

ArticleWorld journal of experimental medicine2026

Changes in the metabolism of axillary lymph node cells as a predictor of regional metastasis in breast cancer.

Marina A Senchukova, Azamat T Ishemgulov, Sergey N Letuta, Natalia V Saidler, Dmitry G Tagabilev

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Article in World journal of experimental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Marina A SenchukovaScientific and Clinical Center No. 3, Petrovsky National Research Centre of Surgery, Moscow 108840, Troitsk, Russia. masenchukova@yandex.com.
Azamat T IshemgulovDepartment of Biophysics, Orenburg State University, Orenburg 460018, Russia.
Sergey N LetutaDepartment of Biophysics, Orenburg State University, Orenburg 460018, Russia.
Natalia V SaidlerDepartment of Pathology, Orenburg Regional Cancer Clinic, Orenburg 460021, Orenburgskaya Oblast', Russia.
Dmitry G TagabilevScientific and Clinical Center No. 3, Petrovsky National Research Centre of Surgery, Moscow 108840, Troitsk, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent studies have shown that the delayed luminescence of erythrosine (DLE) indicators differs between tumor and nontumor breast tissue in patients with breast cancer (BC).

aimTo study the features of metabolism of axillary lymph node (ALN) cells and their relationship with regional metastasis in BC patients.

methodsThis prospective, single-center, observational cohort study included 69 patients with newly diagnosed BC. DLE indicators were measured for 152 ALNs. DLE decay kinetics were recorded using flash photolysis. A control circuit interfaced the analog measuring devices and digital data processing systems. Eighty-eight and 74 ALN samples were stained with antibodies against vascular cell adhesion molecule-1 (VCAM-1) and C-X-C motif chemokine receptor 4 (CXCR4), respectively. Statistical calculations were performed using Statistica version 12.0 software.

resultsSinglet oxygen-sensitized delayed fluorescence (SOSDF) indicators were significantly lower, whereas phosphorescence and thermally activated delayed fluorescence indicators were significantly higher in ALNs with metastases than in those without metastases (

conclusionThese results indicate that metastatic LNs exhibit greater oxygen consumption by tumor cells and that changes in tumor cell metabolism are associated with increased CXCR4 and VCAM-1 expression in ALNs.

Indexed as

Breast cancerC-X-C motif chemokine receptor 4Delayed fluorescence of erythrosineLymph node metastasesSinglet oxygen-sensitized delayed fluorescenceVascular cell adhesion molecule-1

Identifiers

PMID42780585
PMCPMC13598457

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