ArticleBiochemistry research international2026
Pogostemon Cablin Aqueous Extract (PCAE) Induces Mitotic Delay by Downregulating CDC2/Cyclin B1 in TNBC Cells (MDA-MB-231).
Article in Biochemistry research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pogostemon cablin (PC) is a traditional medicinal herb with diverse pharmacological activities, including reported anticancer effects. However, its therapeutic potential in triple-negative breast cancer (TNBC) many unknowns remain. In this article, we investigated the antiproliferative activity of PC aqueous extract (PCAE) in MDA-MB-231 TNBC cells and explored the factors responsible for its anticancer effects. The cytotoxicity was evaluated by the MTT method, whereas apoptosis, cell-cycle distribution, intracellular reactive oxygen species (ROS), mitochondrial membrane potential (MMP), and mitotic progression were analyzed. The expression of
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