ArticleFrontiers in immunology2026
Defective IL-17 production is associated with reduced IL-1β levels in response to
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Introduction: Children with latent tuberculosis (LTBI) infection are more susceptible to Methods: In this study, we compared the immune cell phenotypes of freshly isolated PBMCs as well as Mtb antigen specific cytokine and chemokine production in HIV-LTBI+ and HIV+LTBI+ children. We also identified the factors responsible for reduced IL-1β production by PBMCs from HIV+LTBI+ children. Results: We found that compared to HIV-LTBI+ (healthy LTBI+) children, HIV+ children with LTBI have significantly fewer exhausted (LAG3+) NK cells and specific CD8+ cell subsets in freshly isolated PBMCs. We also found that in response to Mtb antigens, PBMCs from HIV+LTBI+ children produced less IL-1β, IL-17, IFN-γ and MCP-1 than PBMCs from HIV-LTBI+ children. Recombinant IL-17 significantly increased the production of IL-1β, MCP-1 and MIP-1α; increased the expansion of CD4+CD45RO+CCR7+CD62L+ T cells; and significantly decreased the number of CD3-CD56+CD158b (KIR2DL) expressing NK cells by CFP-10 and ESAT-6 stimulated PBMCs from HIV+LTBI+ children. Discussion: We demonstrated that defective IL-17 production is associated with decreased secretion of the protective cytokines IL-1β, MCP-1 and MIP-1α in HIV+LTBI+ children. These findings highlight the need to investigate IL-17 mediated mechanisms to develop interventions for children with concurrent HIV and latent tuberculosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.