ArticleFrontiers in aging neuroscience2026
Functional brain network connectivity patterns associated with midlife metabolic syndrome and cognitive vulnerabilities.
Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Metabolic syndrome (MetS) may amplify neural vulnerability via vascular and inflammatory pathways. Existing literature suggests there are alterations to functional brain network organization in adults with MetS, though the specific patterns and their relation to cognitive vulnerabilities warrant further investigation, particularly in a midlife sample. Method: Cognitively unimpaired, community-dwelling adults ( Results: MetS participants showed reduced within-network connectivity in the default mode network (DMN; adjusted Conclusion: Midlife MetS was associated with modest reductions in within-network DMN connectivity, with abdominal obesity and low HDL cholesterol as the primary contributing MetS components. Reduced DMN connectivity was associated with poorer verbal fluency performance. These findings suggest that subtle differences in higher-order functional brain network organization associated with metabolic syndrome can be detected during midlife and are related to cognitive functioning, highlighting the importance of prevention and intervention of cardiometabolic risk in midlife to preserve network integrity and cognitive health.
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