ArticleFrontiers in pediatrics2026
Parent-driven transmission, off-label SMZ-TMP, and severe pertussis prediction in infants under 2 months: a real-world observational cohort of 527 cases.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Despite high DTaP coverage, pertussis resurgence persists. Infants under 2 months of age face severe outcomes due to vaccine ineligibility and rising macrolide-resistant Objective: To analyze epidemiology, clinical profiles, and antimicrobial management of hospitalized pertussis infants under 2 months of age, identifying risk factors for severity and evaluating real-world SMZ-TMP use. Methods: Retrospective study of PCR/culture-confirmed pertussis infants hospitalized at Shenzhen Children's Hospital (2015-2024). Data included transmission sources, clinical severity, and antimicrobial regimens. Logistic regression analysis was performed to analyze the risk factors for severe pertussis, and a Results: Among 321 infants with a history of exposure, parents constituted the primary infection source (46.1%, 148/321). 25 infants with Conclusion: In infants under 2 months of age with pertussis, parents are the primary source of infection. In infants under 2 months of age with macrolide-resistant pertussis, treatment with SMZ-TMP was effective and no severe adverse reactions were observed.
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