Evidence map›Paper›PMID 42780392›Full record

ArticleGenes & diseases2027

Steatotic liver-derived extracellular vesicles deliver ACSL4 to potentiate hepatic ischemia-reperfusion injury by orchestrating a ferroptosis-mitochondrial apoptosis cascade.

Hangcheng Zhao, Jialing Zhao, Danfeng Zhou, Yunguo Lei, Zhikun Liu, Jun Chen, Peiyang Hu, Xiao Xu, Haiyang Xie, Qiang Wei

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & diseases, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hangcheng ZhaoInstitute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China.
Jialing ZhaoNHC Key Laboratory of Combined Multi-organ Transplantation, Institute of Organ Transplantation, Zhejiang University, Hangzhou, Zhejiang 310003, China.
Danfeng ZhouZhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, China.
Yunguo LeiInstitute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China.
Zhikun LiuSchool of Clinical Medicine, Hangzhou Medical College, Hangzhou, Zhejiang 310053, China.
Jun ChenDepartment of Hepatobiliary & Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang 310014, China.
Peiyang HuDepartment of Traumatology, Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang People's Hospital), Hangzhou Medical College, Taizhou, Zhejiang 317200, China.
Xiao XuInstitute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China.
Haiyang XieNHC Key Laboratory of Combined Multi-organ Transplantation, Institute of Organ Transplantation, Zhejiang University, Hangzhou, Zhejiang 310003, China.
Qiang WeiNHC Key Laboratory of Combined Multi-organ Transplantation, Institute of Organ Transplantation, Zhejiang University, Hangzhou, Zhejiang 310003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Steatotic liver grafts exhibit heightened susceptibility to hepatic ischemia-reperfusion injury (HIRI), contributing to poor outcomes in liver transplantation; however, the underling mechanisms remain incompletely defined. Here, we demonstrate that extracellular vesicles derived from steatotic livers (HFD-EVs) exacerbate HIRI by delivering acyl-CoA synthetase long-chain family member 4 (ACSL4) to hepatocytes, thereby triggering a ferroptosis-mitochondrial apoptosis cascade. Proteomic profiling revealed that HFD-EVs are enriched with ACSL4 and other pro-ferroptotic mediators, but deficient in mitochondrial oxidative phosphorylation components. In a murine model, administration of HFD-EVs to lean mice prior to ischemia-reperfusion significantly aggravated liver injury, apoptosis, and inflammatory responses compared to EVs from healthy livers.

Indexed as

ACSL4Extracellular vesiclesFerroptosisHepatic ischemia–reperfusion injuryMitochondrialapoptosisSteatotic liver graft

Identifiers

PMID42780392
PMCPMC13597912

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.