ArticleFrontiers in immunology2026
Shoutai Wan regulates maternal-fetal immune tolerance in lactate dehydrogenase A knockdown model mice to prevent miscarriage.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Problem: Maternal-fetal immune tolerance is vital for a healthy pregnancy. However, the metabolic factors governing this balance are not yet clear. This study investigates the role of LDHA in this process and explores how Shoutai Wan (STW) regulates uterine immune cells through LDHA. Methods: A uterine-specific LDHA-knockdown model was established by injecting AAV9- Results: Uterine LDHA knockdown decreased embryo number and disrupted maternal-fetal interface morphology. STW treatment reversed these effects. IHC showed that STW increased CD4 Conclusion: Uterine LDHA inhibition disrupts maternal-fetal immune tolerance in pregnant CBA/J mice. STW treatment restores this balance in sh-
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