ArticleFrontiers in microbiology2026
Thermal modulation of transcriptional states, biofilm architecture and survival strategies in
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inroduction: Methods: We integrated transcriptomic profiling with confocal and electron microscopy at different growth temperatures. Additionally, we conducted adaptive laboratory evolution (ALE) under progressive heat stress coupled with whole-genome sequencing. Results: Transcriptomes from cultures grown at 16 °C, 35 °C, 38 °C, and 41 °C were linked to physiology and biofilm structure, whereas ALE revealed strategies under warming stress. Low temperature promoted a biofilm-competent program driving motility and exopolysaccharide production. Conversely, growth at 41 °C induced a stress-survival state with repression of cooperative traits-quorum sensing-and the activation of DNA repair and oxidative stress responses. Exploratory network analyses predicted NarL, NtrC, CysB, and CsgD as putative components of a temperature-responsive control core, with a reduction in regulatory connectivity at 38 °C, representing a transitional stop-and-reprogram state. Finally, ALE selected for recurrent clone-specific mutations in Discussion: Overall, our findings show how
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