ArticleFrontiers in bioinformatics2026
Datamonkey 3: browser-native molecular evolution analysis.
Article in Frontiers in bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
We present Datamonkey 3, a browser-native implementation of the Datamonkey web platform for molecular evolutionary analysis. By utilizing WebAssembly to execute the HyPhy analysis engine on the client side, Datamonkey 3 removes the dependency on remote computational clusters for standard analyses. This architecture ensures data sovereignty by processing sequences locally and enables an interactive workflow with immediate feedback. The platform provides a comprehensive suite of statistical methods for detecting natural selection and recombination, supported by a data curation system that identifies and corrects common formatting errors. Additionally, Datamonkey 3 incorporates data-driven runtime estimation and interactive results visualization. By shifting the computational burden to the client, Datamonkey 3 establishes a sustainable, privacy-preserving infrastructure model that scales with the user base, demonstrating the viability of client-side genomic inference. While tailored for evolutionary analysis of selection and recombination, this browser-native architecture offers a generalizable blueprint for deploying complex bioinformatic tools without server-side dependencies. Datamonkey 3 is freely available at https://v3.datamonkey.org, and all source code is available from https://github.com/veg/datamonkey3.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.