In one paragraphArticle in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
28 authors.
Hannah C AinsworthDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-1185-0695 Ekaterina S KhvatkovaDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0009-0000-7797-0767 Marc SudmanDivision of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-9061-8274 Miranda C MarionDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0003-4487-8010 Kaiyu JiangDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
John F BohnsackDepartment of Pediatrics, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, Utah, USA.ORCID 0000-0003-1392-9727 Mary E ComeauDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0001-7079-8781 Patrick M GaffneyGenes and Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-1580-869X Johannes-Peter HaasGerman Center for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany.ORCID 0000-0001-8117-1298 Timothy D HowardCenter for Precision Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA.ORCID 0000-0003-2518-4902 Kimme HyrichCentre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0001-8242-9262 Judith A JamesArthritis and Clinical Immunology Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA.ORCID 0000-0002-9574-7355 Peter A NigrovicDivision of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2126-3702 Marite RyggDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0001-5190-151X Samantha L SmithNIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0002-4108-8497 Vibeke VidemDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.ORCID 0000-0002-1042-3889 Lucy R WedderburnInfection, Immunity and Inflammation Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK.ORCID 0000-0002-7495-1429 Carol A WiseMcDermott Center for Human Growth and Development, Departments of Orthopedic Surgery and Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-6790-2194 Rae S M YeungCell and Systems Biology Program, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.ORCID 0000-0003-2361-725X Susan D ThompsonDivision of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0003-4130-2796 Grant S SchulertDivision of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0001-5923-7051 Sampath PrahaladDepartments of Pediatrics and Human Genetics, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0003-3489-1756 John BowesCentre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, School of Biological Sciences, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.ORCID 0000-0003-4659-031X Sheila T Angeles-HanDivision of Rheumatology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.ORCID 0000-0002-9552-6464 James N JarvisDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.ORCID 0000-0002-1878-0717 Carl D LangefeldDepartment of Biostatistics and Data Science, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.ORCID 0000-0002-4266-6949 Funding
Pediatric Rheumatology Tissue RepostoryP01AR048929 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI THOMPSON, SUSAN D · 2003 to 2015
$13.6MJoint Biology Consortium Resource-based CenterP30AR070253 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic, Jeffrey Andrew Sparks · 2016 to 2026
$9.4MOklahoma Rheumatic Disease Research Cores Center (Overall Application)P30AR073750 · NIAMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI JUDITH A JAMES · 2018 to 2026
$8.5MTissue Repository CoreP30AR070549 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI Leah Claire Kottyan · 2016 to 2026
$7.7MPredicting uveitis onset in children with juvenile idiopathic arthritisR01EY030521 · NEI · CINCINNATI CHILDRENS HOSP MED CTR · PI ANGELES-HAN, SHEILA THERESE · 2019 to 2023
$3.2MBridging the gap between GWAS and mechanism in JIAR01AR073201 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Peter A Nigrovic · 2019 to 2026
$3.2MEpigenetic Mechanisms That Drive Genetic Risk in Juvenile ArthritisR01AR078785 · NIAMS · UNIVERSITY OF WASHINGTON · PI JAMES N JARVIS · 2022 to 2026
$3.1MDefining the complex genetics of JIARC1AR058587 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI THOMPSON, SUSAN D · 2009 to 2010
$1.0MGenetics of Juvenile Idiopathic Arthritis and SubtypesR01AR057106 · NIAMS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI LANGEFELD, CARL D, THOMPSON, SUSAN D · 2009 to 2010
$592kNEI NIH HHS R01 EY030521NIAMS NIH HHS P01 AR048929NIAMS NIH HHS P30 AR070253NIAMS NIH HHS P30 AR070549NIAMS NIH HHS P30 AR073750NIAMS NIH HHS R01 AR057106NIAMS NIH HHS R01 AR073201NIAMS NIH HHS R01 AR078785NIAMS NIH HHS RC1 AR058587
6 · The paper itselfAbstract
Juvenile idiopathic arthritis (JIA), the most common class of pediatric rheumatic diseases, can lead to joint damage and extra-articular features including uveitis. Early treatment can improve functional outcomes; but many patients do not respond to first-line treatments. We present a JIA Immunochip-based association analysis of rheumatoid factor-negative polyarticular JIA and oligoarticular JIA. This study spans 3,939 cases and 14,412 controls, including 1,123 cases and 1,356 controls not previously analyzed. We identify 41 (14 novel) JIA risk regions and report a JIA polygenic risk score that also associates with age of onset. Functional mechanisms presented include: a novel interaction between HLA-A*02:01 and
Identifiers
PMID42780307
PMCPMC13596673
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