Evidence map›Paper›PMID 42780283›Full record

ArticleResearch square2026

Distinct structural mechanisms drive gain-of-function activation of TMEM16E in gnathodiaphyseal dysplasia.

Eleonora Di Zanni, Omar E Alvarenga, Nicole Rychlik, Zhang Feng, Elizabeth D Kim, George Khelashvili, Alessio Accardi

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eleonora Di ZanniDepartment of Anesthesiology, Weill Cornell Medicine.
Omar E AlvarengaDepartment of Anesthesiology, Weill Cornell Medicine.
Nicole RychlikDepartment of Anesthesiology, Weill Cornell Medicine.
Zhang FengDepartment of Anesthesiology, Weill Cornell Medicine.ORCID 0000-0002-5623-7416
Elizabeth D KimDepartment of Anesthesiology, Weill Cornell Medicine.ORCID 0000-0002-6240-484X
George KhelashviliDepartment of Computational and Systems Biomedicine, Weill Cornell Medicine.ORCID 0000-0001-7235-8579
Alessio AccardiDepartment of Anesthesiology, Weill Cornell Medicine.ORCID 0000-0002-6584-0102

Funding

TRD #3: An automated and streamlined pipeline for in-situ molecular microscopyP41GM103310 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI KIEFT, JEFFREY S · 2012 to 2021
$14.7M
Structure and function of chloride channels, transporters and scramblasesR35GM152012 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI Alessio Accardi · 2024 to 2026
$1.6M
Identification of potential drug binding sites within allosteric networks in cyclic nucleotide modulated channelsF32GM145091 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KIM, ELIZABETH DIONE · 2022 to 2023
$139k
NIGMS NIH HHS F32 GM145091NIGMS NIH HHS P41 GM103310NIGMS NIH HHS R35 GM152012
6 · The paper itself

Abstract

In cells TMEM16E (ANO5) mediates Ca

Identifiers

PMID42780283
PMCPMC13596665

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.