ArticleFrontiers in pediatrics2026
Three decades of recombinant human growth hormone research in children born small for gestational age: a bibliometric analysis (1996-2025).
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
Background: Recombinant human growth hormone (rhGH) has been a standard therapy for short children born small for gestational age (SGA) since 2001 (FDA) and 2003 (EMA), yet no bibliometric analysis has mapped this field's intellectual structure. Materials and methods: Publications were retrieved from four databases, Lens.org ( Results: The field showed three phases temporally aligned with regulatory milestones, stabilizing at a compound annual growth rate (CAGR) of 6.3% (2011-2025). Hormone Research in Paediatrics ( Conclusion: The rhGH-SGA literature shows a maturing research landscape with increasing thematic diversification from efficacy studies toward molecular and genetic diagnostics and patient-centered outcomes. Keyword trend analysis reveals measurable shifts in terminology, study methodology, and patient populations, identifying gaps and emerging directions that can inform future trial design and funding priorities.
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