Evidence map›Paper›PMID 42780253›Full record

ArticleResearch square2026

Semi-metric optimal transport enables robust spatial multi-omics integration.

Shuang Wang, Yikun Bai, Ricardo Melo Ferreira, Huy Tran, Hengrong Du, Xuhong Zhang, Ying-Hua Cheng, Angela R Sabo, Sanjay Jain, Pierre C Dagher and 4 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shuang WangDepartment of Computer Science, Indiana University Bloomington, Bloomington, IN, USA.
Yikun BaiDepartment of Mathematics, Purdue University, West Lafayette, IN, USA.
Ricardo Melo FerreiraDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-2063-9744
Huy TranDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Hengrong DuDepartment of Mathematics and Computer Science, Fisk University, Nashville, TN, USA.
Xuhong ZhangDepartment of Computer Science, Indiana University Bloomington, Bloomington, IN, USA.
Ying-Hua ChengDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Angela R SaboDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Sanjay JainDivision of Nephrology, Department of Medicine and Kidney Translational Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA.
Pierre C DagherDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-3321-5561
Tarek M El-AchkarDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-4645-3614
Michael T EadonDepartment of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0003-3066-2876
Soheil KolouriDepartment of Computer Science, Vanderbilt University, Nashville, TN, USA.
Juexin WangDepartment of Biomedical Engineering and Informatics, Indiana University Indianapolis, Indianapolis, IN, USA.ORCID 0000-0002-2260-4310

Funding

Kidney single cell and spatial molecular atlas project - KIDSSMAPU54DK134301 · NIDDK · WASHINGTON UNIVERSITY · PI JAIN, SANJAY · 2022 to 2025
$7.8M
Identify functional modules in spatial omics atlas with cellular community motifsR01LM015252 · NLM · INDIANA UNIVERSITY INDIANAPOLIS · PI Juexin Wang, DONG XU · 2026 to 2026
$1.4M
SCH: Graph-based Spatial Transcriptomics Computational Methods in Kidney DiseasesR01DK138504 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Michael Thomas Eadon, Qin Ma · 2023 to 2026
$1.1M
NIDDK NIH HHS R01 DK138504NIDDK NIH HHS U54 DK134301NLM NIH HHS R01 LM015252
6 · The paper itself

Abstract

Integrating heterogeneous spatial multi-omics data to uncover underlying biological and pathological mechanisms remains a major challenge, while existing approaches generally lack mathematically justified distances for comparing complex spatial tissues. We introduce

Identifiers

PMID42780253
PMCPMC13596659

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.