Evidence map›Paper›PMID 42780249›Full record

ArticleResearch square2026

Transient architecture of the embryonic pancreas determines endocrine mass.

Neha H Ahuja, Christopher Chaney, Tyler Bierschenk, Tuli Pramanik, Austin Mills, Peter M Luo, Mitzy A Cowdin, Jinlong Lin, Jun Tsunezumi, Kevin M Dean and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Neha H AhujaDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Christopher ChaneyDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.ORCID 0000-0002-4144-4180
Tyler BierschenkDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Tuli PramanikDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Austin MillsDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Peter M LuoDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Mitzy A CowdinDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Jinlong LinLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Jun TsunezumiInternal Medicine (Division of Nephrology), University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Kevin M DeanLyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.ORCID 0000-0003-0839-2320
Denise K MarcianoInternal Medicine (Division of Nephrology), University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.
Thomas J CarrollDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.ORCID 0000-0002-8322-4928
Ondine CleaverDepartment of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, Texas, USA 75390.

Funding

Engineering erythropoietin-producing cellsR24DK106743 · NIDDK · ROGOSIN INSTITUTE · PI CARROLL, THOMAS JOSEPH, CLEAVER, ONDINE B · 2015 to 2019
$7.0M
UTSW-UNC Center for Cell Signaling AnalysisRM1GM145399 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Kevin Michael Dean, Klaus M. Hahn · 2022 to 2026
$6.2M
The Role of Nephronectin in Glomerular Development and FunctionR01DK118032 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI MARCIANO, DENISE K · 2018 to 2022
$1.8M
Role of Afadin in 3D epithelial plexus morphogenesis and beta cell massR01DK116622 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CLEAVER, ONDINE B, MARCIANO, DENISE K · 2019 to 2022
$1.7M
Endothelial Signals During OrganogenesisR01DK079862 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI CLEAVER, ONDINE B · 2007 to 2011
$1.5M
Elucidating novel mechanisms in the pathogenesis of Alport syndromeR01DK141873 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DENISE K MARCIANO · 2024 to 2026
$1.3M
Spinning Disk Confocal for UT SouthwesternS10OD028630 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2020 to 2020
$600k
Mechanisms of Cellular Communication: The Role of Merlin in Pancreatic DevelopmentK99DK140516 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI Neha Ahuja · 2025 to 2026
$179k
NIDDK NIH HHS K99 DK140516NIDDK NIH HHS R01 DK079862NIDDK NIH HHS R01 DK116622NIDDK NIH HHS R01 DK118032NIDDK NIH HHS R01 DK141873NIDDK NIH HHS R24 DK106743NIGMS NIH HHS RM1 GM145399NIH HHS S10 OD028630
6 · The paper itself

Abstract

During organogenesis, epithelial tissues undergo extensive three-dimensional remodeling while simultaneously generating specialized cell types, yet whether transient architectural states actively instruct lineage allocation remains unclear. During pancreas development,

Indexed as

cell fateCrumbs3endocrine massepithelial architectureepitheliumEzrinHippolumenlumenogenesisMerlinmorphogenesisNf2organogenesisPancreasPI3KplexusRab11Rab5vesicle traffickingYap1

Identifiers

PMID42780249
PMCPMC13596649

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.