ArticlebioRxiv : the preprint server for biology2026
A mouse model of myotonic dystrophy type 1 exhibits pain-like behavior and peripheral nociceptor hyperexcitability.
Tyler S Nelson, Aida Calderon-Rivera, Sara Hestehave, Santiago Loya-Lopez, Kimberly Gomez, Paz Duran, Rajesh Khanna
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Tyler S NelsonDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, and Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-6675-4820 Aida Calderon-RiveraDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, and Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Sara HestehaveDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010, USA.
Santiago Loya-LopezDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, and Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Kimberly GomezDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, and Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL 32610, USA.
Paz DuranDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010, USA.
Rajesh KhannaDepartment of Pharmacology and Therapeutics, McKnight Brain Institute, and Center for Advanced Pain Therapeutics and Research (CAPToR), College of Medicine, University of Florida, Gainesville, FL 32610, USA.ORCID 0000-0002-9066-2969 Funding
Sentrin proteases, CRMP2 deSUMOylation, and Chronic PainR01NS120663 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2020 to 2021
$2.6MValidation of Neuropilin-1 Receptor Signaling in Nociceptive ProcessingRF1NS131165 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2023 to 2023
$2.0MAntagonists of CRMP2 Phosphorylation for Chemotherapy-Induced Peripheral NeuropathyR61NS126026 · NINDS · UNIVERSITY OF FLORIDA · PI KHANNA, RAJESH · 2022 to 2022
$1.4MDissecting the Parabrachial Nucleus’s Role in the Development and Maintenance of Neuropathic PainK00NS124190 · NINDS · UNIVERSITY OF FLORIDA · PI Tyler Scott Nelson · 2023 to 2026
$346kLymphocyte Antigen 6 (Ly6) Proteins: New Players in Chronic PainK99NS134965 · NINDS · UNIVERSITY OF FLORIDA · PI GOMEZ, KIMBERLY · 2023 to 2023
$236kNINDS NIH HHS K00 NS124190NINDS NIH HHS K99 NS134965NINDS NIH HHS R01 NS120663NINDS NIH HHS R61 NS126026NINDS NIH HHS RF1 NS131165
6 · The paper itselfAbstract
Pain is a prevalent and disabling symptom of myotonic dystrophy type 1 (DM1), yet its underlying mechanisms remain poorly understood. Using HSA LR20b transgenic mice, we found multimodal mechanical and thermal hypersensitivity. Whole-cell electrophysiological recordings demonstrated depolarized resting membrane potentials and increased action potential firing selectively in small- and medium-diameter dorsal root ganglion neurons. These findings identify peripheral nociceptor sensitization as a potential mechanism contributing to pain in DM1.
Identifiers
PMID42780153
PMCPMC13596546
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