Evidence map›Paper›PMID 42780122›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Multi-population genome-wide association meta-analysis of acute and chronic pancreatitis.

Samuel Khodursky, Renae Judy, Sarah Abramowitz, Michael G Levin, Scott M Damrauer

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samuel KhodurskyDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Renae JudyDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Sarah AbramowitzDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Michael G LevinCorporal Michael J. Crescenz VA Medical Center, Philadelphia, PA, USA.ORCID 0000-0002-9937-9932
Scott M DamrauerDepartment of Surgery, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0001-8009-1632

Funding

BLRD VA IK2 BX006551
6 · The paper itself

Abstract

Acute (AP) and chronic (CP) pancreatitis are major causes of gastrointestinal morbidity. However, the genetic architectures of AP and CP remain incompletely defined, as does the degree to which the two conditions share a common genetic basis. Here we report a multi-population GWAS meta-analysis of both AP and CP across five biobanks, comprising 23,292 individuals with and 1,748,420 individuals without AP across five populations and 9,866 individuals with and 1,627,720 individuals without CP across three populations. We identified 16 and 14 genome-wide significant loci for AP and CP, respectively. Combining nearest-gene assignment, fine-mapping, MAGMA, and colocalization with pancreatic eQTLs, we prioritized 7 genes for AP and 5 genes for CP using two or more approaches, including three previously unreported candidates:

Identifiers

PMID42780122
PMCPMC13596603

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.