ArticlebioRxiv : the preprint server for biology2026
The La Crosse virus M segment determines virus isolate cell-to-cell spread and virulence.
Molly V Durawa, Nicole C Rondeau, Sophie N Spector, Sara A Thannickal, Abbie E Weight, Ariana Dedvukaj, Matthew C Lutchko, Helen M Lazear, Kenneth A Stapleford
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
9 authors.
Molly V DurawaDepartment of Microbiology, New York University Grossman School of Medicine. New York, NY, USA.
Nicole C RondeauDepartment of Microbiology, New York University Grossman School of Medicine. New York, NY, USA.
Sophie N SpectorDepartment of Microbiology, New York University Grossman School of Medicine. New York, NY, USA.
Sara A ThannickalDepartment of Microbiology, New York University Grossman School of Medicine. New York, NY, USA.
Abbie E WeightDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.
Ariana DedvukajDepartment of Microbiology, New York University Grossman School of Medicine. New York, NY, USA.
Matthew C LutchkoDepartment of Microbiology, New York University Grossman School of Medicine. New York, NY, USA.
Helen M LazearDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill. Chapel Hill, NC, USA.ORCID 0000-0002-8649-4579 Kenneth A StaplefordDepartment of Microbiology, New York University Grossman School of Medicine. New York, NY, USA.
Funding
Molecular Biology of Viral Diseases Predoctoral Training GrantT32AI007419 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Mark T Heise, CARY A MOODY · 1993 to 2026
$4.7MHost Factors Controlling Neuroinvasive Flavivirus PathogenesisR01AI170625 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LAZEAR, HELEN · 2022 to 2025
$1.6MViral and host genetic determinants of La Crosse virus neuroinvasive diseaseR01AI203471 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Helen Lazear · 2026 to 2026
$772kHost and viral factors modulating La Crosse virus pathogenesisF31AI202949 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Abbie Elizabeth Weight · 2026 to 2026
$44kNIAID NIH HHS F31 AI202949NIAID NIH HHS R01 AI170625NIAID NIH HHS R01 AI203471NIAID NIH HHS T32 AI007419
6 · The paper itselfAbstract
La Crosse virus (LACV) is an orthobunyavirus spread by mosquitoes in North America and can cause severe neurological disease. Despite this burden, there is a lack of LACV antiviral treatments as our fundamental understanding of how LACV spreads and causes disease remains incomplete. To investigate LACV biology, we took advantage of two genetically similar LACV lineage I isolates (LACV
Identifiers
PMID42780118
PMCPMC13596476
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