Evidence map›Paper›PMID 42780109›Full record

ArticlebioRxiv : the preprint server for biology2026

NEMP1 organizes the meiotic telomere-LINC interface to control chromosome movement and telomere integrity.

Hui Zhang, Ling Zhang, Stephanie A Pangas, Andrea Jurisicova, Helen McNeill

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hui ZhangDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-8893-0234
Ling ZhangDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0001-7660-7878
Stephanie A PangasDepartment of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.ORCID 0000-0001-5748-5844
Andrea JurisicovaLunenfeld Tanenbaum Research Institute, Sinai Health Systems, Toronto, ON, Canada Department of Physiology, University of Toronto, Toronto, ON, Canada Department of Obstetrics and Gynaecology, University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-2166-4298
Helen McNeillDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-1126-5154

Funding

Dissecting the function of Nemp1, a nuclear envelope protein critical for mammalian fertilityR01HD108639 · NICHD · WASHINGTON UNIVERSITY · PI Helen McNeill · 2023 to 2026
$2.3M
NICHD NIH HHS R01 HD108639
6 · The paper itself

Abstract

Nuclear Envelope Membrane Protein 1 (NEMP1) is highly expressed in oocytes and required for fertility, yet its meiotic function remains poorly understood. Here, we identify NEMP1 as a critical organizer of meiotic telomere-nuclear envelope coupling and chromosome dynamics. Loss of NEMP1 causes telomere aggregation, loss of shelterin protection, telomere shortening, persistent DNA damage, aberrant non-homologous end joining, and chromosome end-to-end fusion, ultimately leading to aneuploidy in mouse oocyte. NEMP1 is required during early fetal meiotic prophase I for telomere-nuclear envelope attachment, bouquet formation, homolog pairing, and synapsis. Live-cell imaging revealed robust rapid prophase movements in wild-type meiocytes, which were nearly abolished by NEMP1 loss and restored by NEMP1-GFP re-expression. Mechanistically, NEMP1 associates with telomeric DNA and the SUN1-KASH5 LINC machinery, and SUN1-GFP restores chromosome movement in Nemp1-deficient meiocytes. Together, these findings establish NEMP1 as a nuclear-envelope organizer linking telomere protection, chromosome dynamics, and genome integrity during mammalian oogenesis.

Indexed as

Female fertilityGenome stabilityMeiotic telomeresNuclear envelopeRapid prophase movements

Identifiers

PMID42780109
PMCPMC13596425

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.