Evidence map›Paper›PMID 42780094›Full record

ArticlebioRxiv : the preprint server for biology2026

Apoptotic Quality Control of Cellular Competence Limits Cryptic Germinal Center B Cell States.

Chen-Hao Yeh, Nathan Shenkerman, Shengli Song, Hélène Kirshner, Akiko Watanabe, Dongmei Liao, Xiaoe Liang, Wenli Zhang, Kevin Wiehe, Garnett Kelsoe and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chen-Hao YehDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.
Nathan ShenkermanDuke Human Vaccine Institute, Duke University, Durham, North Carolina 27705, USA.
Shengli SongDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.ORCID 0000-0003-0507-5194
Hélène KirshnerDuke Human Vaccine Institute, Duke University, Durham, North Carolina 27705, USA.
Akiko WatanabeDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.
Dongmei LiaoDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.
Xiaoe LiangDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.
Wenli ZhangDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.
Kevin WieheDuke Human Vaccine Institute, Duke University, Durham, North Carolina 27705, USA.
Garnett KelsoeDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.
Masayuki KuraokaDepartment of Integrative Immunobiology, Duke University, Durham, North Carolina 27705, USA.

Funding

Nonhuman primate studies for development of a prototype HIV vaccine that induces broadly neutralizing antibodiesUM1AI144371 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2019 to 2025
$190.4M
Optimizing the Generation of Monoclonal Antibodies for Prevention and Treatment of HSV DiseaseR01AI177673 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI Betsy C. Herold, Masayuki Kuraoka · 2023 to 2026
$2.4M
NIAID NIH HHS R01 AI177673NIAID NIH HHS UM1 AI144371
6 · The paper itself

Abstract

Germinal center (GC) B cells undergo extensive apoptosis, but how this process shapes evolving GC populations remains unclear. Using mice lacking intrinsic apoptotic effectors BAK and BAX in B cells, we found that mitochondrial apoptosis was dispensable for affinity maturation but critical for controlling GC size and cellular composition, showing that GC population dynamics and affinity maturation can be uncoupled. BAK/BAX-deficient mice mounted enlarged and prolonged GC responses, largely due to the accumulation of non-proliferating Ki-67

Indexed as

clonal selectiongerminal centermitochondrial apoptosismutational tolerancenon-proliferating DZ cells

Identifiers

PMID42780094
PMCPMC13596569

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.