ArticleFrontiers in medicine2026
Clinical features of concurrent systemic lupus erythematosus and renal biopsy-proven antineutrophil cytoplasmic antibody-associated vasculitis: a retrospective analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Antineutrophil cytoplasmic antibody (ANCA) positivity is not uncommon in patients with systemic lupus erythematosus (SLE), however, the diagnosis of concurrent SLE and ANCA-associated vasculitis (AAV) is challenging because SLE tends to mask the clinical manifestations of AAV. Since the kidney is the most frequently affected organ in AAV, we consider that SLE patients with concurrent renal biopsy-proven AAGN warrant the greatest clinical attention. Methods: We enrolled two patients with newly diagnosed SLE and renal biopsy-proven AAV glomerulonephritis (AAGN). After a literature search, another 57 similar patients were identified. Then the clinical characteristics of these patients were analyzed. Results: Including the two newly reported patients, a total of 51 female and 8 male patients were included. Compared with patients with AAGN alone, patients with combined lupus nephritis (LN) and AAGN had higher SLEDAI scores [14.00 (10.00-18.00) vs. 5.00 (2.50-12.50), Conclusion: For ANCA-positive SLE patients, renal injury may be caused by LN, LN combined with AAGN, or even isolated AAGN. So renal biopsy plays a crucial role in guiding the accurate choice of therapeutic strategy. Further studies are required owing to the heterogeneity of case sources.
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