Evidence map›Paper›PMID 42780071›Full record

ArticleResearch and practice in thrombosis and haemostasis2026

Genetic and hemostatic characterization of PAI-1 deficiency and isolated hyperfibrinolysis: data from the RBiN study.

Bauke Haisma, Thomas Nieuwenstein, Sanna R Rijpma, Annet Simons, Nicole M A Blijlevens, Waander L van Heerde, Saskia E M Schols

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Bauke HaismaDepartment of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.
Thomas NieuwensteinDepartment of Hematologie, Radboud University Medical Center, Hemophilia Treatment Center Nijmegen-Eindhoven-Maastricht, Nijmegen, the Netherlands.
Sanna R RijpmaDepartment of Hematologie, Radboud University Medical Center, Hemophilia Treatment Center Nijmegen-Eindhoven-Maastricht, Nijmegen, the Netherlands.
Annet SimonsDepartment of Hematologie, Radboud University Medical Center, Hemophilia Treatment Center Nijmegen-Eindhoven-Maastricht, Nijmegen, the Netherlands.
Nicole M A BlijlevensDepartment of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.
Waander L van HeerdeDepartment of Hematologie, Radboud University Medical Center, Hemophilia Treatment Center Nijmegen-Eindhoven-Maastricht, Nijmegen, the Netherlands.
Saskia E M ScholsDepartment of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Plasminogen activator inhibitor 1 (PAI-1) is a key regulator of fibrinolysis, and its deficiency causes bleeding symptoms. PAI-1 deficiency is rare, and pathogenic Objectives: To assess Methods: This substudy of the nationwide, cross-sectional RBiN cohort included patients with PAI-1 deficiency, isolated hyperfibrinolysis, and RCFDs. Results: Fourteen patients with PAI-1 deficiency, 15 with isolated hyperfibrinolysis, and 214 with RCFDs were included. Conclusion: PAI-1 deficiency and isolated hyperfibrinolysis showed enhanced plasmin generation, but were not linked to

Indexed as

Coagulation Protein DisordersFibrinolysisHemostasisPlasminogen Activator Inhibitor 1AdolescentAdultChildCross-Sectional StudiesFemaleFibrinolysinGenetic Predisposition to DiseaseHemorrhagic DisordersHumansMaleMiddle AgedPolymorphism, GeneticFibrinolysinPlasminogen Activator Inhibitor 1SERPINE1 protein, humanexomeexome sequencinggenetic polymorphismgenetic promoter regiongenotypeinherited blood coagulation disordersmutationplasminogen activator inhibitor-1 deficiency

Identifiers

PMID42780071
PMCPMC13597289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.