Evidence map›Paper›PMID 42780053›Full record

Observational studyResearch and practice in thrombosis and haemostasis2026

A miniaturized chemiluminescent thrombin generation assay to assess the effect of APCC in persons with hemophilia A with inhibitors: an observational study.

Aernoud P Bavinck, Theodora J Steeghs, Lisa van Engelshoven, Nerissa M M Coolen, Claudia J van de Ridder, Beata Baran, Jerzy Windyga, Nicole M A Blijlevens, Saskia E M Schols, Cornelis van 't Veer and 1 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Research and practice in thrombosis and haemostasis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aernoud P BavinckDepartment of Hematology, Radboud University Medical Centre, The Netherlands.
Theodora J SteeghsDepartment of Hematology, Radboud University Medical Centre, The Netherlands.
Lisa van EngelshovenEnzyre, Nijmegen, The Netherlands.
Nerissa M M CoolenEnzyre, Nijmegen, The Netherlands.
Claudia J van de RidderEnzyre, Nijmegen, The Netherlands.
Beata BaranLaboratory of Hemostasis and Metabolic Diseases, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
Jerzy WindygaLaboratory of Hemostasis and Metabolic Diseases, Institute of Hematology and Transfusion Medicine, Warsaw, Poland.
Nicole M A BlijlevensDepartment of Hematology, Radboud University Medical Centre, The Netherlands.
Saskia E M ScholsDepartment of Hematology, Radboud University Medical Centre, The Netherlands.
Cornelis van 't VeerEnzyre, Nijmegen, The Netherlands.
Waander L van HeerdeEnzyre, Nijmegen, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Monitoring of bypassing agents in persons with hemophilia A with inhibitors is complicated, especially when multiple treatment modalities are combined. The thrombin generation assay (TGA) might address these issues but is hampered by limited availability and standardization. Objectives: To assess the performance of a novel microfluidic chemiluminescent TGA (microfluidic-TGA Methods: The microfluidic-TGA Results: Increasing concentrations of APCC spiked in FVIII-deficient plasma significantly increased PH, AUC, and VI and shortened lag time in the microfluidic-TGA Conclusions: The microfluidic-TGA

Indexed as

Blood CoagulationBlood Coagulation Factor InhibitorsBlood Coagulation FactorsFactor VIIIHemophilia ALuminescent MeasurementsThrombinBlood Coagulation TestsHumansMaleMicrofluidicsanti-inhibitor coagulant complexBlood Coagulation Factor InhibitorsBlood Coagulation FactorsFactor VIIIThrombinAPCCblood coagulation testshemophilia Amicrofluidic

Identifiers

PMID42780053
PMCPMC13597294

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.