Evidence map›Paper›PMID 42780025›Full record

ArticlebioRxiv : the preprint server for biology2026

Extracellular matrix proteoglycans lumican and biglycan promote innate immune signals and viral clearance in HSV-1 infections of mouse corneas.

George Maiti, Madhuri Koduri, Elizabeth Shin, Yoonchul Shin, Trisha Sinha, Alireza Khodadadi-Jamayran, Hongmin Yun, Anthony J St Leger, Shukti Chakravarti

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

George MaitiDepartment of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-6701-5499
Madhuri KoduriDepartment of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0002-3375-9713
Elizabeth ShinRegeneron Pharmaceuticals, Inc. Tarrytown, NY, USA.
Yoonchul ShinDepartment of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA.
Trisha SinhaDepartment of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA.
Alireza Khodadadi-JamayranApplied Bioinformatics Laboratories, NYU Grossman School of Medicine, New York, NY, USA.
Hongmin YunSchool of Medicine, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Anthony J St LegerSchool of Medicine, Department of Ophthalmology, University of Pittsburgh, Pittsburgh, PA, USA.
Shukti ChakravartiDepartment of Ophthalmology, NYU Grossman School of Medicine, New York, NY, USA.ORCID 0000-0001-7543-1903

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MARK Reid PHILIPS · 1985 to 2026
$83.1M
Extracellular matrix proteoglycans regulate toll-like receptors 4 and 9 - Equipment SupplementR01EY030917 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, SHUKTI · 2020 to 2023
$1.8M
Multispectral imaging & analysis of intact tissue sections w/ the Perkin Elmer VectraS10OD021747 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LOOMIS, CYNTHIA A · 2016 to 2016
$359k
NCI NIH HHS P30 CA016087NEI NIH HHS R01 EY030917NIH HHS S10 OD021747
6 · The paper itself

Abstract

The extracellular matrix (ECM) regulates innate immunity, but its role in HSV-1 keratitis is unclear. Here, we identify the ECM proteoglycans lumican (Lum) and biglycan (Bgn) as key regulators of early antiviral defense in the cornea.

Indexed as

biglycanCCL2corneal organoidECMHSV-1innate immunitykeratitislumican

Identifiers

PMID42780025
PMCPMC13596386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.